Disease, Menetrier

Disease, Menetrier
A premalignant disorder of the stomach characterized by overgrowth of the stomach lining (gastric mucosa), nausea and vomiting and abdominal pain, and hypoalbuminemia (low blood serum level of albumin) due to loss of albumin by the stomach. The abnormalities of the stomach in Menetrier's disease are highly characteristic with giant folds, excess mucus secretion by the lining of the stomach, and hypochlorhydria (decreased acid secretion by the stomach). The disease tends to lead to stomach cancer. Symptoms include nausea, vomiting, pain in the abdomen, swelling, poor appetite, and weight loss. The cause of Menetrier's disease is not known, although infections with cytomegalovirus and Helicobacter pylori have been suspected to play a role. The overgrowth of the stomach lining (gastric hypertrophy) in Menetrier's disease appears to be due to activation of the receptor for epidermal growth factor in the stomach. Treatment of severe disease can involve partial or complete removal of the stomach. Treatment with a monoclonal antibody against the epidermal growth factor receptor has been reported to result in marked reduction in the frequency of nausea and vomiting, an increase in the serum albumin concentration, and improvement in the abnormalities of the stomach. (New England Journal of Medicine 343:1697, 2000) History and nomenclature: The disease was first described in 1888 by P. Menetrier. His name has an acute accent on the first two e's and is pronounced may-nay-tree-yeh. Menetrier disease is also called hypoproteinemic hypertrophic gastropathy.

Medical dictionary. 2011.

Поможем написать курсовую

Look at other dictionaries:

  • Ménétrier's disease — Not to be confused with Ménière s disease. Ménétrier s disease Classification and external resources Ménétrier s disease. In this case, there was so much pit hyperplasia that the giant folds appeared to be covered by a myriad of polyps resembling …   Wikipedia

  • Ménétrier-Syndrom — Klassifikation nach ICD 10 K29.6 Sonstige Gastritis …   Deutsch Wikipedia

  • Disease — Illness or sickness often characterized by typical patient problems (symptoms) and physical findings (signs). Disruption sequence: The events that occur when a fetus that is developing normally is subjected to a destructive agent such as the… …   Medical dictionary

  • Ménétrier's disease — a disorder in which gross enlargement (see hypertrophy) of the cells of the mucous membrane lining the stomach is associated with anaemia. P. Ménétrier (1859 1935), French physician …   Medical dictionary

  • Ménétrier's disease — a disorder in which gross enlargement (see hypertrophy) of the cells of the mucous membrane lining the stomach is associated with anaemia [Ménétrier (1859–1935), French physician] …   The new mediacal dictionary

  • Ménétrier — Pierre E., French physician, 1859–1935. See M. disease, M. syndrome …   Medical dictionary

  • Pierre Eugène Ménétrier — (1859 1935) was a French pathologist from Paris. He is remembered for his description of a rare gastric disorder that was later to become known as Ménétrier s disease. In 1888 Ménétrier first described this disorder while performing post mortem… …   Wikipedia

  • Digestive disease — Classification and external resources MeSH D004066 All diseases that pertain to the gastrointestinal tract are labelled as digestive diseases. This includes diseases of the esophagus, stomach, first, second, and third part of the …   Wikipedia

  • Enfermedad de Menetrier — Saltar a navegación, búsqueda La enfermedad de Ménétrier, también conocida como gastropatía hipersecretoria hiperplásica y gastropatía hipertrófica perdedora de proteínas, es un trastorno de la mucosa del estómago en la que se corruga, se… …   Wikipedia Español

  • Crohn's disease — Classification and external resources The three most common sites of intestinal involvement in Crohn s disease are ileal, ileocolic and colonic.[ …   Wikipedia

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”