Fc

See F. fragment.

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family coping; fasciculus cuneatus; fast component [of a neuron]; febrile convulsions; feline conjunctivitis; ferric chloride; ferric citrate; fibrocyte; finger clubbing; finger counting; flow compensation; fluorescein conjugated; fluorocarbon; fluorocytosine; fold change; Foley catheter; follicle culture; foster care; fowl cholera; free cholesterol; frontal cortex; functional castration

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[fragment, crystallizable] originally, the fragment, not containing antigen combining sites, obtained by papain cleavage of the IgG molecule; now generally used as an adjective, e.g., Fc region, segment, to refer to the part of any immunoglobulin monomer comprising the hinge region and C_H2, C_H3, and C_H4 domains of both heavy chains. The Fc region contains the allotypic markers and mediates all biologic activities including complement activation, binding to cell-surface receptors (Fc receptors, IgE receptors), and transplacental transport of IgG. Cf. Fab.