- A metabolite of 17β-estradiol, commonly found in urine, ovaries, and placenta; has considerably less biologic activity than the parent hormone. SYN: follicular hormone, folliculin, ketohydroxyestrin, oestrone.
* * *es·trone 'es-.trōn or chiefly Brit oes·trone 'ē-.strōn n a natural estrogenic hormone that is a ketone C18H22O2 found in the body chiefly as a metabolite of estradiol, is also secreted esp. by the ovaries, and is used to treat various conditions (as ovarian failure and menopausal symptoms) relating to estrogen deficiency see THEELIN
* * *es·trone (esґtrōn) an oxidation product of estradiol, the first of the estrogens isolated in pure form, found in human pregnancy urine, male human urine, human plasma, mare pregnancy urine, stallion urine, human ovarian follicular fluid and placenta, and palm kernel oil; also produced synthetically. It is less potent than estradiol but more so than estriol and is metabolically convertible to estradiol; it is secreted by the ovary but circulating estrone is for the most part derived from peripheral metabolism of estradiol and especially androstenedione. [USP] a preparation of estrone; used in estrogen replacement therapy for hypogonadism, ovariectomy, primary ovarian failure, atrophic vaginitis, vasomotor menopausal symptoms, and vulvar atrophy, and in the treatment of dysfunctional uterine bleeding and advanced prostatic carcinoma; administered intramuscularly or intravaginally.
Medical dictionary. 2011.