A metabolite of 17β-estradiol, commonly found in urine, ovaries, and placenta; has considerably less biologic activity than the parent hormone. SYN: follicular hormone, folliculin, ketohydroxyestrin, oestrone.

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es·trone 'es-.trōn or chiefly Brit oes·trone 'ē-.strōn n a natural estrogenic hormone that is a ketone C18H22O2 found in the body chiefly as a metabolite of estradiol, is also secreted esp. by the ovaries, and is used to treat various conditions (as ovarian failure and menopausal symptoms) relating to estrogen deficiency see THEELIN

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es·trone (esґtrōn) an oxidation product of estradiol, the first of the estrogens isolated in pure form, found in human pregnancy urine, male human urine, human plasma, mare pregnancy urine, stallion urine, human ovarian follicular fluid and placenta, and palm kernel oil; also produced synthetically. It is less potent than estradiol but more so than estriol and is metabolically convertible to estradiol; it is secreted by the ovary but circulating estrone is for the most part derived from peripheral metabolism of estradiol and especially androstenedione. [USP] a preparation of estrone; used in estrogen replacement therapy for hypogonadism, ovariectomy, primary ovarian failure, atrophic vaginitis, vasomotor menopausal symptoms, and vulvar atrophy, and in the treatment of dysfunctional uterine bleeding and advanced prostatic carcinoma; administered intramuscularly or intravaginally.

Medical dictionary. 2011.

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  • estrone — noun a naturally occurring weak estrogenic hormone secreted by the mammalian ovary; synthesized (trade name Estronol) and used to treat estrogen deficiency • Syn: ↑oestrone, ↑theelin, ↑Estronol • Usage Domain: ↑trade name (for: ↑Estronol) …   Useful english dictionary

  • Estrone sulfotransferase — In enzymology, an estrone sulfotransferase (EC number| is an enzyme that catalyzes the chemical reaction:3 phosphoadenylyl sulfate + estrone ightleftharpoons adenosine 3 ,5 bisphosphate + estrone 3 sulfateThus, the two substrates of this… …   Wikipedia

  • estrone — noun Etymology: estrane Date: 1933 a natural estrogenic hormone that is a ketone C18H22O2 found in the body chiefly as a metabolite of estradiol, that is also secreted especially by the ovaries, and that is used to treat various conditions (as… …   New Collegiate Dictionary

  • estrone — /es trohn/, n. 1. Biochem. an estrogenic hormone, C18H22O2, produced by the ovarian follicles and found during pregnancy in urine and placental tissue. 2. Pharm. a commercial form of this compound, obtained from the urine of pregnant women or… …   Universalium

  • estrone — noun An estrogenic hormone excreted by the ovaries; sometimes manufactured synthetically for use in cases of estrogen deficiency. Syn: theelin …   Wiktionary

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