ergotamine

ergotamine
C33H35N5O5; an alkaloid from ergot, used for the relief of migraine; it is a potent stimulant of smooth muscle, particularly of the blood vessel s and the uterus, and produces adrenergic blockade (chiefly of the alpha receptors); hydrogenated e., dihydroergotamine, is less toxic and has fewer side effect s. Also available as e. tartrate.

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er·got·a·mine (.)ər-'gät-ə-.mēn n an alkaloid that is derived from ergot and is used chiefly in the form of its tartrate (C33H35N5O5)2·C4H6O6 esp. in treating migraine

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n.
a drug that causes constriction of blood vessels and is used to relieve migraine. It is administered by mouth or in suppositories. Common side-effects are nausea and vomiting, and ergotism may develop as a result of high doses; because of this it has largely been superseded by 5HT1 agonist. Trade names: Cafergot, Migril.

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er·got·amine (ər-gotґə-min) an alkaloid derived from ergot, consisting of lysergic acid, ammonia, proline, phenylalanine, and pyruvic acid combined in amide linkages; used in the treatment of migraine and cluster headaches.

Medical dictionary. 2011.

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  • Ergotamine — Systematic (IUPAC) name (6aR,9R) N ((2R,5S,10aS,10bS) 5 benzyl 10b hydroxy 2 methyl 3,6 dioxooctahydro 2H oxazolo[3,2 a] pyrrolo[2,1 c]pyrazin 2 yl) 7 methyl 4,6,6a,7,8,9 hexahydroindolo[4,3 fg] quinoline 9 car …   Wikipedia

  • Ergotamine — Structure de l ergotamine Général No CAS …   Wikipédia en Français

  • ergotamine — [ ɛrgɔtamin ] n. f. • v. 1970; de ergot (de seigle) ♦ Biochim. Alcaloïde extrait de l ergot de seigle, parfois utilisé dans le traitement des migraines. ● ergotamine nom féminin Alcaloïde de l ergot de seigle, vasoconstricteur (utilisé pour… …   Encyclopédie Universelle

  • ergotamine — [ʉr gät′ə mēn΄, ʉr gät′əmin] n. [ ERGOT + AMINE] an alkaloid, C33H35O5N5, isolated from ergot and used esp. in the treatment of migraine headaches …   English World dictionary

  • ergotamine tartrate — [USP] the tartrate salt of ergotamine, administered orally, sublingually, by oral inhalation, or rectally in the treatment of migraine and cluster headaches …   Medical dictionary

  • ergotamine — noun Etymology: International Scientific Vocabulary Date: 1921 an alkaloid C33H35N5O5 derived from ergot that is used chiefly in the form of its tartrate especially in treating migraine …   New Collegiate Dictionary

  • ergotamine — /err got euh meen , min/, n. Pharm. a crystalline, water soluble polypeptide, C33H35N5O5, obtained from ergot, used to stimulate uterine contractions during labor and in the treatment of migraine. [1920 25; ERGOT + AMINE] * * * …   Universalium

  • ergotamine — noun /ɜːˈɡɒtəmiːn/ An alkaloid, extracted from ergot, that causes constriction of blood vessels and has been used to treat migraine; it is related to lysergic acid …   Wiktionary

  • ergotamine — n. chemical substance used as a medication against migraines and to accelerate childbirth …   English contemporary dictionary

  • ergotamine — [ə: gɒtəmi:n] noun Medicine an ergot alkaloid that causes constriction of blood vessels and is used to treat migraine …   English new terms dictionary

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