Deficiency, adenosine deaminase (ADA)
- Deficiency, adenosine deaminase (ADA)
- A genetic (inherited) condition that results in a immune deficiency disorder called severe combined immunodeficiency disease. Adenosine deaminase is an enzyme that plays a key role in salvaging purine molecules. ADA deficiency is of special interest in the history of genetics. The first successful instance of gene therapy in humans was carried out in 1990 by Drs. W. French Anderson, R. Michael Blaese and Kenneth W. Culver who infused genetically engineered blood cells to repair ADA deficiency.
Medical dictionary.
2011.
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Adenosine deaminase (ADA) deficiency — A genetic (inherited) condition that results in a immune deficiency disorder called severe combined immunodeficiency disease. Adenosine deaminase is an enzyme that plays a key role in salvaging purine molecules. ADA deficiency is of special… … Medical dictionary
Adenosine deaminase — (also known as ADA) is an enzyme (EC number|3.5.4.4) involved in purine metabolism. It is needed for the breakdown of adenosine from food and for the turnover of nucleic acids in tissues.ReactionsADA irreversibly deaminates adenosine, converting… … Wikipedia
adenosine deaminase deficiency — (ADA deficiency) a genetic disorder affecting about one baby in 25,000 and characterized by a defect in adenosine deaminase (ADA), an enzyme that is involved in purine metabolism. Deficiency of this enzyme results in selective damage to the… … Medical dictionary
adenosine deaminase deficiency — ADA deficiency a genetic disorder affecting about one baby in 25,000 and characterized by a defect in adenosine deaminase (ADA), an enzyme that is involved in purine metabolism. Deficiency of this enzyme results in selective damage to the… … The new mediacal dictionary
Adenosine deaminase deficiency — Infobox Disease Name = PAGENAME Caption = DiseasesDB = 260 ICD10 = ICD10|D|81|3|d|80 ICD9 = ICD9|279.2 ICDO = OMIM = 102700 MedlinePlus = eMedicineSubj = eMedicineTopic = MeshID = Adenosine deaminase deficiency, also called ADA deficiency or ADA… … Wikipedia
adenosine deaminase — n an enzyme which catalyzes the conversion of adenosine to inosine and whose deficiency causes a form of severe combined immunodeficiency disease as a result of the accumulation of toxic metabolites which inhibit DNA synthesis abbr. ADA * * *… … Medical dictionary
adenosine deaminase deficiency — a severe immune system disorder caused by a genetic inability to produce adenosine deaminase. Also called ADA deficiency. * * * … Universalium
adenosine deaminase deficiency — a severe immune system disorder caused by a genetic inability to produce adenosine deaminase. Also called ADA deficiency … Useful english dictionary
Дефицит Аденозин Дезаминазы (Ада Дефицит) (Adenosine Deaminase Deficiency, Ada Deficiency) — наследственное заболевание, встречающееся у одного из каждых 25 000 младенцев и характеризующееся дефицитом содержания в организме аденозин дезаминазы (АДА) (adenosine deaminase (ADA)), фермента, участвующего в метаболизме пуринов. Дефицит… … Медицинские термины
adenosine deaminase — noun an enzyme found in mammals that can catalyze the deamination of adenosine into inosine and ammonia ADA deficiency can lead to one form of severe combined immunodeficiency disease the gene encoding ADA was one of the earlier human genes to be … Useful english dictionary
