dystrophin

dystrophin
A protein found in the sarcolemma of normal muscle; it is missing in individuals with pseudohypertrophic muscular dystrophy and in other forms of muscular dystrophy; its role may be in the linkage of the cytoskeleton of the muscle cell to extracellular protein. SYN: distropin, dystropin.

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dys·tro·phin 'dis-trə-.fin n a protein of high molecular weight that is associated with a transmembrane glycoprotein complex of skeletal muscle cells and is absent in Duchenne muscular dystrophy and deficient or of abnormal molecular weight in Becker muscular dystrophy

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dys·troph·in (disґtrə-fin) a protein found in skeletal and cardiac muscle, normally in a tightly bound complex with sarcolemmal glycoproteins; mutations in the gene encoding it have been associated with Duchenne muscular dystrophy, Becker muscular dystrophy, and occasionally also other types of skeletal muscle dysfunction. See also dystrophin-glycoprotein complex, under complex.

Medical dictionary. 2011.

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  • Dystrophin — is a rod shaped cytoplasmic protein, and a vital part of a protein complex that connects the cytoskeleton of a muscle fiber to the surrounding extracellular matrix through the cell membrane. This complex is variously known as the costamere or the …   Wikipedia

  • Dystrophin — Masse/Länge Primärstruktur 3685 Aminosäuren …   Deutsch Wikipedia

  • dystrophin — dystrophin. См. дистрофин. (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) …   Молекулярная биология и генетика. Толковый словарь.

  • dystrophin-glycoprotein complex — (DGC) a large oligomeric complex of proteins and glycoproteins of the sarcolemma that are critical to the stability of muscle fiber membranes and to the linking of the actin cytoskeleton to the extracellular matrix; it includes dystrophin,… …   Medical dictionary

  • dystrophin — noun Etymology: dystrophy + 1 in Date: 1987 a protein that is associated with a transmembrane complex of skeletal muscle cells and that is absent in Duchenne muscular dystrophy and deficient or defective in Becker muscular dystrophy …   New Collegiate Dictionary

  • dystrophin — Protein (400 kD) from skeletal muscle that is missing in Duchenne muscular dystrophy. Its exact role is not yet clear, though it seems to be associated with the cytoplasmic face of the sarcolemma and T tubules and may form part of the membrane… …   Dictionary of molecular biology

  • dystrophin — noun A cytoplasmic structural protein that is deficient in some forms of muscular dystrophy …   Wiktionary

  • dystrophin — [dɪs trəʊfɪn] noun Biochemistry a protein found in skeletal muscle, which is absent in sufferers from muscular dystrophy …   English new terms dictionary

  • dystrophin — dys·tro·phin …   English syllables

  • dystrophin — /dɪsˈtroʊfən/ (say dis trohfuhn) noun a cytoplasmic protein important in the maintenance of muscular structure …  

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