dolichol

dolichol
Polyisoprenes in which the terminal member is saturated and oxidized to an alcohol, usually phosphorylated and often glycosylated; found in endoplasmic reticulum, but not in mitochondrial or plasma membranes; urinary levels are elevated in disorders exhibiting abnormal skin, rectal, or brain profiles in electron microscopy of biopsies.
- d. phosphate an intermediate in the glycosylation of proteins and lipids; contains 11–24 isoprene units; a product of the isoprenylation pathway; participates in the formation of glycosylphosphatidylinositol anchors of proteins in biomembranes.

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dol·i·chol (dolґĭ-kol) any of a group of polyisoprenoid lipids, containing 13–24 isoprene units and a terminal hydroxyl group, occurring in the endoplasmic reticulum. It is also the major lipid component of neuromelanin

Medical dictionary. 2011.

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  • dolichol — Terpenoids with 13 24 isoprene units and a terminal phosphorylated hydroxyl group. Function as transmembrane carriers for glycosyl units in the biosynthesis of glycoproteins and glycolipids …   Dictionary of molecular biology

  • dolichol — noun any polyterpenoid having a single hydroxyl group on the terminal carbon atom, and the terminal isoprene residue being saturated; a dihydropolyprenol …   Wiktionary

  • Dolichol — Do|li|chol [griech. dolichós = lang, weit; ↑ ol (1)], das; s, e: H161C99 CH2OH; ein langkettiger, aus 20 Isopreneinheiten aufgebauter Alkohol (↑ Isoprenoid), der zusammen mit den Homologen aus 18–22 Isopreneinheiten (Dolichole) in tierischen… …   Universal-Lexikon

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