dibucaine number

dibucaine number
A test for differentiation of one of several forms of atypical pseudocholinesterases that are unable to inactivate succinylcholine at normal rates; based upon percent inhibition of the enzymes by dibucaine, normal enzyme has a DN of 75 and above, heterozygous atypical enzyme has a DN of 40-70, and homozygous atypical enzyme has a DN of less than 20. SEE ALSO: fluoride number.

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dibucaine number n a number expressing the percentage by which cholinesterase activity in a serum sample is inhibited by dibucaine

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an expression of the percentage of inhibition of the enzyme cholinesterase in a serum sample by dibucaine; used to differentiate between normal and abnormal serum cholinesterase phenotypes. Normal or usual is about 80; intermediate is about 60; abnormal or atypical is about 20. Abbreviated DN.

Medical dictionary. 2011.

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