A chemical waste molecule that is generated from muscle metabolism. Creatinine is produced from creatine, a molecule of major importance for energy production in muscles. Approximately 2% of the body's creatine is converted to creatinine every day. Creatinine is transported through the bloodstream to the kidneys. The kidneys filter out most of the creatinine and dispose of it in the urine. Although it is a waste, creatinine serves a vital diagnostic function. Creatinine has been found to be a fairly reliable indicator of kidney function. As the kidneys become impaired the creatinine will rise. Abnormally high levels of creatinine thus warn of possible malfunction or failure of the kidneys, sometimes even before a patient reports any symptoms. It is for this reason that standard blood and urine tests routinely check the amount of creatinine in the blood. Normal levels of creatinine in the blood are approximately 0.6 to 1.2 milligrams (mg) per deciliter (dl) in adult males and 0.5 to 1.1 milligrams per deciliter in adult females. (In the metric system, a milligram is a unit of weight equal to one-thousandth of a gram, and a deciliter is a unit of volume equal to one-tenth of a liter.) Muscular young or middle-aged adults may have more creatinine in their blood than the norm for the general population. Elderly persons, on the other hand, may have less creatinine in their blood than the norm. Infants have normal levels of about 0.2 or more, depending on their muscle development. A person with only one kidney may have a normal level of about 1.8 or 1.9. Creatinine levels that reach 2.0 or more in babies and 10.0 or more in adults may indicate the need for a dialysis machine to remove wastes from the blood. Certain drugs can sometimes cause abnormally elevated creatinine levels.
* * *
A component of urine and the final product of creatine catabolism; formed by the nonenzymatic dephosphorylative cyclization of phosphocreatine to form the internal anhydride of creatine.

* * *

cre·at·i·nine krē-'at-ən-.ēn, -ən-ən n a white crystalline strongly basic compound C4H7N3O formed from creatine and found esp. in muscle, blood, and urine

* * *

a substance derived from creatine and creatine phosphate in muscle. Creatinine is excreted in the urine.

* * *

cre·at·i·nine (kre-atґĭ-nin) the cyclic anhydride of creatine, produced as the final product of decomposition of phosphocreatine. It is excreted in the urine; measurements of excretion rates are used as diagnostic indicators of kidney function (see creatinine clearance, under clearance) and muscle mass and can be used to simplify other clinical assays. [NF] a preparation of creatinine, used as a bulking agent in freeze-drying.

Medical dictionary. 2011.

Игры ⚽ Поможем решить контрольную работу

Look at other dictionaries:

  • Créatinine — Général Nom IUPAC 2 amino 3 méthyl 4H imidazol 5 one No CAS …   Wikipédia en Français

  • Creatinine — Créatinine Créatinine Général Nom IUPAC créatinine No CAS …   Wikipédia en Français

  • créatinine — [ kreatinin ] n. f. • 1863; de créatine ♦ Biochim. Anhydride de la créatine, dont la mesure dans l urine est utilisée pour évaluer la fonction rénale. ● créatinine nom féminin Substance azotée provenant de la dégradation de la créatine. (La… …   Encyclopédie Universelle

  • creatinine — by 1847, from CREATINE (Cf. creatine) + chemical suffix INE (Cf. ine) (2) …   Etymology dictionary

  • creatinine — [krē at′ə nēn΄, krē at′ənin] n. [Ger kreatinin < kreatin (see CREATINE) + INE3] the anhydride of creatine, C4H7N3O, found in blood, muscle, and esp. urine, where measurement of its excretion is used to evaluate kidney function …   English World dictionary

  • Creatinine — Not to be confused with creatine. Creatinine …   Wikipedia

  • creatinine — n. a substance derived from creatine and creatine phosphate in muscle. Creatinine is excreted in the urine …   The new mediacal dictionary

  • creatinine —    It is the waste product of creatine, an enzyme found in large amounts throughout the tissues, and mainly excreted in the urine. The parent compound creatine enables the body to use the blue flame of anaerobic combustion (as opposed to the… …   Herbal-medical glossary

  • creatinine — kreatininas statusas T sritis chemija formulė Formulę žr. priede. priedas( ai) Grafinis formatas atitikmenys: angl. creatinine rus. креатинин ryšiai: sinonimas – 1,5 dihidro 2 imino 1 metil 4(4H) imidazolonas …   Chemijos terminų aiškinamasis žodynas

  • creatinine — A compound that is excreted from the body in urine. Creatinine levels are measured to monitor kidney function …   English dictionary of cancer terms

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”