cytarabine

cytarabine

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cyt·ar·a·bine sīt-'ar-ə-.bēn n CYTOSINE ARABINOSIDE

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n.
a cytotoxic drug used to suppress the symptoms of some types of leukaemia. It is administered by injection and can damage the normal bone marrow, leading to various blood cell disorders. Other side-effects are nausea, vomiting, mouth ulcers, and diarrhoea. Trade name: Cytosar.

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cy·tar·a·bine (ara-C) (si-tarґə-bēn) [USP] a deoxycytidine analogue, cytosine arabinoside, that is metabolically activated to the triphosphate nucleotide (ara-CTP), which acts as a competitive inhibitor of DNA polymerase and produces S phase–specific cytotoxicity; used as an antineoplastic, generally as part of a combination chemotherapy regimen, in the treatment of acute lymphocytic and acute myelogenous leukemia and the blast phase of chronic myelogenous leukemia, administered intravenously and subcutaneously, and for the prophylaxis and treatment of meningitis associated with leukemia, administered intrathecally. Called also arabinosylcytosine.

Medical dictionary. 2011.

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Look at other dictionaries:

  • Cytarabine — Systematic (IUPAC) name 4 amino 1 [(2R,3S,4R,5R) 3,4 dihydroxy 5 (hydroxymethyl)oxolan 2 yl] pyrimidin 2 one Clinical data AHFS/Drugs.com …   Wikipedia

  • Cytarabine — Structure chimique de l arabinoside de cytosine Général Nom IUPAC 1β arabinofuranosylcytosine …   Wikipédia en Français

  • cytarabine liposome injection — liposomal cytarabine …   Medical dictionary

  • cytarabine — /suy tar euh been /, n. Pharm. a toxic synthetic nucleoside, C9H13N3O5, used as an immunosuppressive and cytotoxic agent in the treatment of certain leukemias. Also cytosine arabinoside, ara C. [CYT(OSINE) + ARAB(INOSIDE) + INE2] * * * …   Universalium

  • cytarabine — noun A particular drug used in chemotherapy. Syn: cytosine arabinoside …   Wiktionary

  • cytarabine — n. a drug that inhibits cell division (see antimetabolite) and is used to suppress the symptoms of acute myeloblastic leukaemia. It is administered by injection and can damage the normal bone marrow, leading to various blood cell disorders. Other …   The new mediacal dictionary

  • cytarabine — An anticancer drug that belongs to the family of drugs called antimetabolites …   English dictionary of cancer terms

  • cytarabine — /suy tar euh been /, n. Pharm. a toxic synthetic nucleoside, C9H13N3O5, used as an immunosuppressive and cytotoxic agent in the treatment of certain leukemias. Also cytosine arabinoside, ara C. [CYT(OSINE) + ARAB(INOSIDE) + INE2] …   Useful english dictionary

  • liposomal cytarabine — a suspension of cytarabine molecules encapsulated in liposomes; it is a sustained release preparation that is injected intrathecally in the treatment of meningitis associated with lymphoma …   Medical dictionary

  • DepoFoam-encapsulated cytarabine — The anticancer drug cytarabine formulated inside small particles of a synthetic lipid material called DepoFoam. This dosage form slowly releases the drug and provides a sustained action …   English dictionary of cancer terms

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