virus-directed enzyme/prodrug therapy

virus-directed enzyme/prodrug therapy: a method of treating tumors by the introduction of a suicide gene (q.v.) into tumor cells by a viral vector, followed by the administration of a nontoxic prodrug that is converted to a toxic agent, resulting in tumor cell death.

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Monoclonal antibody therapy — Each antibody binds only one specific antigen. Monoclonal antibody therapy is the use of monoclonal antibodies (or mAb) to specifically bind to target cells or proteins. This may then stimulate the patient s immune system to attack those cells.… … Wikipedia
ADEPT — (Antibody directed enzyme prodrug therapy) Bagshawe KD. Antibody directed enzyme prodrug therapy (ADEPT) for cancer. Expert Rev Anticancer Ther. 2006; 6(10): 1421 1431.Entrez Pubmed|17069527] is a strategy to overcome the problems of lack of… … Wikipedia
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Discovery and development of HIV-protease inhibitors — Many major physiological processes depend on regulation of proteolytic enzyme activity and there can be dramatic consequences when equilibrium between an enzyme and its substrates is disturbed. In this prospective, the discovery of small molecule … Wikipedia
Thymidine kinase — protein Name = thymidine kinase 1, soluble caption = width = HGNCid = 11830 Symbol = TK1 AltSymbols = EntrezGene = 7083 OMIM = 188300 RefSeq = NM 003258 UniProt = P04183 PDB = ECnumber = 2.7.1.21 Chromosome = 17 Arm = q Band = 23.2… … Wikipedia
Zidovudine — AZT redirects here. For other uses, see AZT (disambiguation). Zidovudine Systematic (IUPAC) name … Wikipedia

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