kinin system

kinin system
the system of proteins involved in the production and destruction of kinins such as bradykinin and kallidin. Kinins are cleaved from precursor substances called kininogens by kallikreins and are rapidly destroyed by kininases. Plasma kallikrein circulates as a proenzyme called prekallikrein and is converted to active form by factor XIIa, which cleaves HMW kininogen, an α2-globulin, to produce bradykinin. Called also kallikrein s.

Medical dictionary. 2011.

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