polyendocrine autoimmune syndromes
- polyendocrine autoimmune syndromes
- polyglandular autoimmune syndromes syndromes comprising combinations of endocrine and nonendocrine autoimmune diseases. Type I is caused by mutations in the autoimmune regulator gene (AIRE, locus: 21q22.3) and occurs in infants and children. It is characterized by the presence of two of three major clinical symptoms: candidiasis, hypoparathyroidism, and adrenal insufficiency. Pernicious anemia, vitiligo, gonadal failure, alopecia, insulin-dependent diabetes, or thyroid autoimmune disease may also occur. Type II is Schmidt s. Called also autoimmune polyendocrine or autoimmune polyglandular s's.
Medical dictionary.
2011.
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