- isotype switch
- the mechanism by which a B cell changes from the production of one isotype to another in response to stimulation by various cytokines.
Medical dictionary. 2011.
isotype switch
Look at other dictionaries:
isotype switching — The switch of immunoglobulin isotype that occurs, for example, when the immune response progresses (IgM to IgG). The switch from IgM to IgG involves only the constant region of the heavy chains (from m to g ), the light chain and variable regions … Dictionary of molecular biology
switch regions — The nucleotide sequences in heavy chain immunoglobulin genes located in the introns at the 5 end of each CH locus concerned with DNA recombination events that lead to changes in the type of heavy chain produced by a B cell, eg. IgM to IgG… … Dictionary of molecular biology
class switch — Change in the isotype of antibody produced after a B cell has encountered an antigen. * * * the mechanism by which a B cell or plasma cell changes from production of IgM to production of IgG, IgA, or IgE. See immunoglobulin genes, under gene … Medical dictionary
Follicular B Cells — The majority of mature B cells in the spleen express high levels of IgM, IgD, and CD23; lower C21; and no CD1 or CD5, readily distinguishing this FO B cell compartment from B1 B cells and MZ B cells. FO B cells organize into the primary follicles … Wikipedia
T-Helferzelle — Aktivierungsablauf der reifen T Lymphozyten T Helferzellen sind eine Gruppe der T Lymphozyten im Blut, die eine Helferfunktion haben. Sie werden anhand der von ihnen ausgeschütteten Zytokine in zwei wichtige Untergruppen (Subpopulationen)… … Deutsch Wikipedia
Antibody — Immunoglobulin redirects here. For the immunoglobulin family, see Immunoglobulin superfamily. Antibodies redirects here. For the film, see Antibodies (film). Each antibody binds to a specific antigen; an interaction similar to a lock and key. An… … Wikipedia
Immunoglobulin class switching — Mechanism of class switch recombination that allows isotype switching in activated B cells Immunoglobulin class switching (or isotype switching or isotypic commutation or class switch recombination(CSR)) is a biological mechanism that changes a B … Wikipedia
Anticuerpo — Molécula de inmunoglobulina con su típica forma de Y. En azul se observan las cadenas pesadas con cuatro dominios Ig, mientras que en verde se muestran las … Wikipedia Español
B cell — B cells are lymphocytes that play a large role in the humoral immune response (as opposed to the cell mediated immune response, which is governed by T cells). The principal functions of B cells are to make antibodies against antigens, perform the … Wikipedia
Klassenwechsel — Als Klassenwechsel (CSR = class switch recombination oder isotype switching) bezeichnet man in der Immunologie einen Isotypenwechsel bei den B Zellen des Immunsystems. Im Laufe einer Immunantwort werden unterschiedliche Isotypen der… … Deutsch Wikipedia
