cholinesterase reactivator

cholinesterase reactivator
A drug that reacts directly with the alkylphosphorylated enzyme to free the active unit; the drugs used therapeutically to reactivate phosphorylated forms of acetylcholinesterase are oximes, e.g., diacetylmonoxime, monoisonitrosoacetone, 2-pralidoxime.

* * *

an agent that restores the activity of acetylcholinesterase that was previously inactivated by an organophosphate compound; see pralidoxime.

Medical dictionary. 2011.

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Look at other dictionaries:

  • obidoxime chloride — A cholinesterase reactivator much like 2 PAM. * * * obi·dox·ime chlo·ride (o″bĭ dokґsēm) a cholinesterase reactivator which has been used to counter organophosphorus poisoning …   Medical dictionary

  • pralidoxime — pral·i·dox·ime .pral i däk .sēm n a substance C7H9ClN2O that restores the reactivity of cholinesterase and is used to counteract phosphorylation (as by an organophosphate pesticide) called also 2 PAM see PROTOPAM * * * pral·i·dox·ime… …   Medical dictionary

  • isonitrosoacetone — A cholinesterase reactivator that can penetrate the blood brain barrier readily and cause significant reactivation of phosphorylated acetylcholinesterase in the central nervous system; used to protect human beings and animals against otherwise… …   Medical dictionary

  • nicotinehydroxamic acid methiodide — An effective cholinesterase reactivator, with actions that are most marked at the skeletal neuromuscular junction; antidotal effects are less striking at autonomic effector sites and insignificant in the central nervous system …   Medical dictionary

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