sulfite oxidase

sulfite oxidase
sul·fite ox·i·dase (sulґfīt okґsĭ-dās) [EC 1.8.3.1] an enzyme of the oxidoreductase class that catalyzes the final reaction in the degradation of sulfur-containing amino acids, oxidizing sulfite to sulfate; it also oxidizes and detoxifies sulfite and sulfur dioxide from exogenous sources. It is a mitochondrial molybdoenzyme that transfers electrons to cytochrome c via its b5 heme. Deficiency of enzyme activity, due to defect in the enzyme protein or to molybdenum cofactor deficiency (q.v.), results in progressive neurologic abnormalities, lens dislocation, and mental retardation.

Medical dictionary. 2011.

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  • sulfite — A salt of sulfurous acid; elevated in cases of molybdenum cofactor deficiency. s. dehydrogenase an oxidoreductase catalyzing the reaction of s. with 2ferricytochrome c and water to sulfate and 2ferrocytochrome c. s …   Medical dictionary

  • List of EC numbers (EC 1) — This list contains a list of EC numbers for the first group, EC 1, oxidoreducatases, placed in numerical order as determined by the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology.EC 1.1 Acting on the CH OH …   Wikipedia

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  • Molybdenum — niobium ← molybdenum → technetium Cr ↑ Mo ↓ W …   Wikipedia

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  • Molybdenum cofactor deficiency — Classification and external resources OMIM 252150 DiseasesDB 29905 eMedicine …   Wikipedia

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