lagging strand

lagging strand
in DNA replication, the strand that is synthesized in the direction opposite that in which the replication fork moves; because it must be synthesized in the 5′ to 3′ direction and the replication fork moves along the strand in the 3′ to 5′ direction, it is replicated in short fragments (Okazaki fragments), which are later joined. Cf. leading strand. See illustration at replication fork, under fork.

Medical dictionary. 2011.

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  • lagging strand — lagging strand. См. отстающая цепь. (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) …   Молекулярная биология и генетика. Толковый словарь.

  • lagging strand — The strand of DNA that is synthesized discontinuously during replication (because DNA synthesis can proceed only in the 5 ?3 direction). See: Okazaki fragment …   Glossary of Biotechnology

  • leading strand — in DNA replication, the strand that is synthesized in the same direction as the replication fork moves, i.e., in the 5′ to 3′ direction; it is synthesized as a continuous strand. Cf. lagging strand. See illustration at replication… …   Medical dictionary

  • отстающая цепь — lagging strand отстающая цепь. Цепь дочерней ДНК, на которой синтез комплементарной цепи во время репликации осуществляется посредством соединения фрагментов Оказаки <Okazaki fragments>. (Источник: «Англо русский толковый словарь… …   Молекулярная биология и генетика. Толковый словарь.

  • Okazaki fragments — DNA replication Okazaki fragments are short molecules of single stranded DNA that are formed on the lagging strand during DNA replication. They are between 1,000 to 2,000 nucleotides long in Escherichia coli and are between 100 to 200 nucleotides …   Wikipedia

  • DNA replication — DNA replication. The double helix is unwound and each strand acts as a template for the next strand. Bases are matched to synthesize the new partner strands. DNA replication is a biological process that occurs in all living organisms and copies… …   Wikipedia

  • Okazaki fragment — An Okazaki fragment is a relatively short fragment of DNA (with an RNA primer at the 5 terminus) created on the lagging strand during DNA replication. The lengths of Okazaki fragments are between 1,000 to 2,000 nucleotides long in E. coli and are …   Wikipedia

  • Telomere — [ chromosomes (grey) capped by telomeres (white)] A telomere is a region of repetitive DNA at the end of chromosomes, which protects the end of the chromosome from destruction. Its name is derived from the Greek nouns telos ( τἐλος ) end and… …   Wikipedia

  • nucleic acid — /nooh klee ik, klay , nyooh /, Biochem. any of a group of long, linear macromolecules, either DNA or various types of RNA, that carry genetic information directing all cellular functions: composed of linked nucleotides. [1890 95; NUCLE(US) + IC;… …   Universalium

  • Primer (molecular biology) — A primer is a strand of nucleic acid that serves as a starting point for DNA synthesis. They are required for DNA replication because the enzymes that catalyze this process, DNA polymerases, can only add new nucleotides to an existing strand of… …   Wikipedia

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