chlorambucil

A nitrogen mustard derivative that depresses lymphocytic proliferation and maturation. SYN: chloraminophene, chloroambucil.

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chlo·ram·bu·cil klōr-'am-byə-.sil, klȯr- n an anticancer drug C₁₄H₁₉Cl₂NO₂ that is a derivative of nitrogen mustard and is used esp. to treat leukemias, multiple myeloma, some lymphomas, and Hodgkin's disease

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n.

an alkylating agents used in chemotherapy, mainly in the treatment of chronic leukaemias. It is given by mouth; prolonged large doses may cause damage to the bone marrow. Trade name: Leukeran.

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chlor·am·bu·cil (klor-amґbu-sil) [USP] an alkylating agent of the nitrogen mustard group, which acts both by cross-linking of DNA and RNA and by inhibiting of protein synthesis, used as an antineoplastic in the treatment of chronic lymphocytic leukemia, Hodgkin and non-Hodgkin lymphomas, Waldenstrцm macroglobulinemia, and multiple myeloma; administered orally. It has also been used as an immunosuppressive in the treatment of steroid-resistant nephrotic syndrome.