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chlo·ram·bu·cil klōr-'am-byə-.sil, klȯr- n an anticancer drug C14H19Cl2NO2 that is a derivative of nitrogen mustard and is used esp. to treat leukemias, multiple myeloma, some lymphomas, and Hodgkin's disease

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an alkylating agents used in chemotherapy, mainly in the treatment of chronic leukaemias. It is given by mouth; prolonged large doses may cause damage to the bone marrow. Trade name: Leukeran.

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chlor·am·bu·cil (klor-amґbu-sil) [USP] an alkylating agent of the nitrogen mustard group, which acts both by cross-linking of DNA and RNA and by inhibiting of protein synthesis, used as an antineoplastic in the treatment of chronic lymphocytic leukemia, Hodgkin and non-Hodgkin lymphomas, Waldenstrцm macroglobulinemia, and multiple myeloma; administered orally. It has also been used as an immunosuppressive in the treatment of steroid-resistant nephrotic syndrome.

Medical dictionary. 2011.

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  • Chlorambucil — Systematic (IUPAC) name 4 [bis(2 chlorethyl)amino]benzenebutanoic acid Clinical data Trade names Leukeran …   Wikipedia

  • Chlorambucil — Général Nom IUPAC acide 4 {4 [bis(2 chloroéthyl)amino]phényl}butanoïque No CAS …   Wikipédia en Français

  • chlorambucil — chlorambucil. См. хлорамбуцил. (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) …   Молекулярная биология и генетика. Толковый словарь.

  • Chlorambucil — Strukturformel Allgemeines Freiname Chlorambucil Andere Namen …   Deutsch Wikipedia

  • chlorambucil — /klaw ram byeuh sil, kloh /, n. Pharm. a nitrogen mustard, C14H19Cl2NO2, used in the treatment of chronic lymphocytic leukemia, malignant lymphomas, and Hodgkin s disease. [1955 60; chlor(oethyl) + am(inophen) + BU(TYRIC ACID), components of the… …   Universalium

  • chlorambucil — noun A particular drug used in chemotherapy …   Wiktionary

  • Chlorambucil — Chlor|ambucil   [k ] das, s, internationaler Freiname für ein zytostatisches Mittel zur peroralen Anwendung aus der Gruppe der Alkylantien, das zur Behandlung von Leukämie, Lymphomen und Karzinomen verwendet wird …   Universal-Lexikon

  • Chlorambucil — Chlo|ram|bu|cil* [... tsi:l] das; s Kunstw.> Bez. für ein ↑zytostatisches Mittel zur ↑peroralen Anwendung gegen Leukämie u. Karzinome …   Das große Fremdwörterbuch

  • chlorambucil — [klɔ: rambjʊsɪl] noun Medicine a drug used in the treatment of cancer. Origin 1950s: from chlor(oethyl)am(inophenyl)bu(tyric acid), the systematic name, + cil …   English new terms dictionary

  • chlorambucil — chlor·am·bu·cil …   English syllables

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