- A nitrogen mustard derivative that depresses lymphocytic proliferation and maturation. SYN: chloraminophene, chloroambucil.
* * *chlo·ram·bu·cil klōr-'am-byə-.sil, klȯr- n an anticancer drug C14H19Cl2NO2 that is a derivative of nitrogen mustard and is used esp. to treat leukemias, multiple myeloma, some lymphomas, and Hodgkin's disease
* * *n.an alkylating agents used in chemotherapy, mainly in the treatment of chronic leukaemias. It is given by mouth; prolonged large doses may cause damage to the bone marrow. Trade name: Leukeran.
* * *chlor·am·bu·cil (klor-amґbu-sil) [USP] an alkylating agent of the nitrogen mustard group, which acts both by cross-linking of DNA and RNA and by inhibiting of protein synthesis, used as an antineoplastic in the treatment of chronic lymphocytic leukemia, Hodgkin and non-Hodgkin lymphomas, WaldenstrÑ†m macroglobulinemia, and multiple myeloma; administered orally. It has also been used as an immunosuppressive in the treatment of steroid-resistant nephrotic syndrome.
Medical dictionary. 2011.