Nikolsky sign

Nikolsky sign
ready separation of the outer layer of the epidermis from the basal layer with sloughing of the skin produced by minor trauma such as a sliding or rubbing pressure on the skin; this may occur in pemphigus, certain hereditary blistering skin diseases, staphylococcal scalded skin syndrome, toxic epidermal necrolysis, and thermal burns.

Positive Nikolsky sign: epidermal detachment caused by mechanical pressure on an area of erythematous skin in toxic epidermal necrolysis.

Medical dictionary. 2011.

Look at other dictionaries:

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  • Nikolsky — Pyotr V., Russian dermatologist, 1858–1940. See N. sign …   Medical dictionary

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