securin

securin
se·cu·rin (sə-kūrґin) a protease inhibitor that binds separase; its degradation releases separase to cleave cohesin and initiate chromatid separation in anaphase. Securin is overexpressed in some pituitary tumors and can act as an oncogene in cultured cells.

Medical dictionary. 2011.

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  • Securin — Securin, einer der Quellflüsse des Tapajoz in Brasilien …   Pierer's Universal-Lexikon

  • Securin — Protbox topfields|Gene= [http://www.ncbi.nih.gov/entrez/query.fcgi?db=nucleotide cmd=search term=U12185 doptcmdl=GenBank] #ID : AAB00106.1 Structure=Unknown|Review= [http://www.ncbi.nih.gov/entrez/query.fcgi?cmd=Retrieve db=PubMed list… …   Wikipedia

  • securin — noun A protein involved in anaphase triggering …   Wiktionary

  • Anaphase-promoting complex — Anaphase Promoting Complex, also called cyclosome (APC/C), is an E3 ubiquitin ligase that marks target cell cycle proteins for degradation by the 26S proteasome. The APC/C is a large complex of 11–13 subunit proteins, including a cullin (Apc2)… …   Wikipedia

  • PTTG1 — Pituitary tumor transforming 1, also known as PTTG1, is a human gene.cite web | title = Entrez Gene: PTTG1 pituitary tumor transforming 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=9232| accessdate = ] …   Wikipedia

  • Spindle checkpoint — The spindle checkpoint blocks the entry of a cell undergoing mitosis into anaphase until all chromosomes are properly attached to the meiotic or mitotic spindle. To achieve proper segregation, the two kinetochores on the sister chromatids must be …   Wikipedia

  • Separase — protein Name=extra spindle pole bodies homolog 1 (S. cerevisiae) caption= width= HGNCid=16856 Symbol=ESPL1 AltSymbols= EntrezGene=9700 OMIM=604143 RefSeq=NM 012291 UniProt=Q14674 PDB= ECnumber=3.4.22.49 Chromosome=12 Arm=q Band=13.13… …   Wikipedia

  • Cohesin — This article is about the protein complex. For the protein domain in cellulose degrading bacteria, see Cohesin domain. Sister chromatid cohesion protein 1 Cohesin complex composed of SCC1 and SMC1 proteins.[1] …   Wikipedia

  • PTTG1 — Transformante tumoral de pituitaria 1 HUGO 9690 Símbolo PTTG1 Símbolos alt. EAP1; HPTTG; MGC126883; MGC138276; PTTG; SECURI …   Wikipedia Español

  • Metastasis — For the musical composition, see Metastasis (Xenakis composition). Metastasis Classification and external resources Cut surface of a liver showing multiple metastat …   Wikipedia

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