MHC restriction

MHC restriction
the phenomenon of certain cell–cell interactions in the immune response occurring only between cells haploidentical for a major histocompatibility complex (MHC). Helper T cells are activated by antigen only when the antigen is “seen” in conjunction with self class II MHC antigens (Ia antigens in mice, HLA-DR antigens in humans) as is the case when antigen is presented by macrophages. Cytotoxic T cells are activated by and kill only cells displaying foreign antigens (e.g., viral antigens or tumor antigens) plus self class I MHC antigens (K or D antigens in mice, HLA-A, -B, or -C antigens in humans).

Medical dictionary. 2011.

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  • MHC restriction — MHC restricted antigen recognition, or MHC restriction, refers to the fact that a given T cell will recognize a peptide antigen only when it is bound to a particular MHC molecule. Normally, as T cells are stimulated only in the presence of self… …   Wikipedia

  • MHC restriction — Restriction on interaction between cells of the immune system because of the requirement to recognize foreign antigen in association with MHC antigens (major histocompatibility antigens). Thus, cytotoxic T cells will only kill virally infected… …   Dictionary of molecular biology

  • MHC-Restriktion — Die MHC Restriktion beschreibt, dass Antigene von T Lymphozyten nur dann erkannt werden können, wenn sie zuvor aufbereitet und auf spezifischen körpereigenen Rezeptoren, den vom Haupthistokompatibilitätskomplex (MHC) codierten Klasse I und Klasse …   Deutsch Wikipedia

  • restriction — 1. The process with which foreign DNA that has been introduced into a prokaryotic cell becomes ineffective. 2. A limitation. asymmetric fetal growth r. normal fetal head size as a result of preferential shunting of blood to b …   Medical dictionary

  • Major histocompatibility complex — The major histocompatibility complex (MHC) is a large genomic region or gene family found in most vertebrates that encodes MHC molecules. MHC molecules play an important role in the immune system and autoimmunity. Proteins are continually… …   Wikipedia

  • Peter C. Doherty — Infobox Scientist name = Peter C. Doherty box width = image size =150px caption = Peter C. Doherty birth date = 15 October 1940 birth place = Brisbane death date = death place = residence = citizenship = nationality = Australia ethnicity = field …   Wikipedia

  • altered self hypothesis — The hypothesis that the T cell receptor in MHC mediated phenomena recognizes a syngeneic MHC Class I or Class II molecule after modification by a virus or certain chemicals. See MHC restriction …   Dictionary of molecular biology

  • class I antigens — major histocompatibility antigens found on virtually every cell except for human erythrocytes; they are found on molecules consisting of two noncovalently bound chains. One, a 44 kD polymorphic glycoprotein partially embedded in the cell membrane …   Medical dictionary

  • antigen presenting cell — A cell that carries on its surface antigen bound to MCH Class I or Class II molecules, and presents the antigen in this context to T cells. Includes macrophages, endothelium, dendritic cells and Langerhans cells of the skin. See also MHC… …   Dictionary of molecular biology

  • histocompatibility antigen — A set of plasmalemmal glycoproteins that are crucial for T cell recognition of antigens. Particularly the HLA system in humans and the H2 system in mice. There are two classes of histocompatibility antigens: (1) Class I; histocompatibility… …   Dictionary of molecular biology

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