hyperacute rejection

hyperacute rejection
graft rejection occurring immediately after transplantation and resulting from the presence of preformed, circulating cytotoxic antibodies against antigens (often non-HLA antigens) on the graft. Antigen-antibody complexes on vascular endothelium initiate an Arthus-type reaction (type III reaction) in which complement activation results in infiltration by neutrophils, endothelial injury, and occlusion of capillaries with fibrin-platelet thrombi; adequate blood flow to the graft is never established.

Medical dictionary. 2011.

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