homology regions

homology regions
regions of immunoglobulin heavy and light chains containing about 110 amino acid residues and forming compact globular domains stabilized by one intrachain disulfide bond; they have a high degree of sequence homology and similar three-dimensional structure. Each variable region (VH and VL) of heavy and light chains and the light chain constant region (CL) are coextensive with a single homology region. Heavy chain constant regions are composed of three (in γ, δ, and α chains) or four (in μ and ε chains) homology regions, CH1, CH2, CH3, and CH4, and a hinge region separating CH1 and CH2.

Medical dictionary. 2011.

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