estrogen receptor

estrogen receptor
(ER) a type of nuclear receptor consisting of a cellular regulatory protein that binds estrogens, found on nearly all cell types, but particularly in estrogen-sensitive tissues such as the uterus and breast. Cytoplasmic levels are measured in surgically removed breast carcinoma; high levels indicate that a positive response to endocrine therapy is likely.

Medical dictionary. 2011.

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  • Estrogen receptor — 1 (ER alpha) A dimer of the ligand binding region of ERα (PDB rendering based on 3erd). Identifi …   Wikipedia

  • Estrogen receptor alpha — Estrogen receptor 1 PDB rendering based on 1a52 …   Wikipedia

  • Estrogen receptor beta — See also: Estrogen receptor Estrogen receptor 2 (ER beta) PDB rendering based on 1hj1 …   Wikipedia

  • Estrogen receptor test — An estrogen receptor test is a lab test to find out if cancer cells have estrogen receptors (proteins to which estrogen will bind). If the cells have estrogen receptors, they may need estrogen to grow, and this may affect how the cancer is… …   Wikipedia

  • estrogen receptor — ER. A protein found inside the cells of the female reproductive tissue, some other types of tissue, and some cancer cells. The hormone estrogen will bind to the receptors inside the cells and may cause the cells to grow. Also called ER …   English dictionary of cancer terms

  • estrogen receptor test — A lab test to find out if cancer cells have estrogen receptors (proteins to which estrogen will bind). If the cells have estrogen receptors, they may need estrogen to grow, and this may affect how the cancer is treated …   English dictionary of cancer terms

  • estrogen receptor negative — ER . Describes cells that do not have a protein to which the hormone estrogen will bind. Cancer cells that are ER do not need estrogen to grow, and usually do not stop growing when treated with hormones that block estrogen from binding. Also… …   English dictionary of cancer terms

  • estrogen receptor positive — ER+. Describes cells that have a protein to which the hormone estrogen will bind. Cancer cells that are ER+ need estrogen to grow, and may stop growing when treated with hormones that block estrogen from binding. Also called ER+ …   English dictionary of cancer terms

  • Selective estrogen receptor modulator — Selective Estrogen Receptor Modulators (SERMs) are a class of medication that acts on the estrogen receptor.cite journal |author=Riggs BL, Hartmann LC|title=Selective estrogen receptor modulators mechanisms of action and application to clinical… …   Wikipedia

  • selective estrogen receptor modulator — n any of a class of drugs (as raloxifene or tamoxifen) that bind with estrogen receptors and act as estrogen agonists in some tissues and estrogen antagonists in other tissues abbr. SERM * * * (SERM) an agent that activates some estrogen… …   Medical dictionary

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