prion protein

prion protein
(PrP) a constitutively expressed cell surface glycoprotein, 33–35 kD, of uncertain function; in humans encoded by the PRNP gene at locus: 20pter-p12. The 27–30 kD protease-resistant core is the functional, and perhaps only, component of prions; several isoforms have been identified and are responsible for prion disease. Extracellular prion protein aggregates into rod-shaped structures that resemble amyloid.

Medical dictionary. 2011.

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  • prion protein — noun A protein found on the surface of many mammalian cell types, especially neurons. The normal function of the prion protein is not known …   Wiktionary

  • prión — m. genét. Partícula infecciosa de naturaleza exclusivamente proteica relacionada con el origen de enfermedades degenerativas del sistema nervioso central. Los priones pueden encontrarse en el organismo sin causar daños, principalmente en el… …   Diccionario médico

  • Prion — DiseaseDisorder infobox Name = Prion Diseases (TSEs) ICD10 = A81 ICD9 = ICD9|046 A prion (IPAEng|ˈpriːɒn [OED|Prion] Audio|Pronunciation prion.ogg|listen) is thought to be an infectious agent that, according to current scientific consensus, is… …   Wikipedia

  • Prion — Prionen (vom engl. Proteinaceous Infectious particle, sowie der Analogie zu Virion) sind Proteine, die im tierischen Organismus sowohl in normalen (physiologischen), aber auch anormalen, und dann krankmachenden (pathogenen) Strukturen… …   Deutsch Wikipedia

  • prion — prion1 /pruy on/, n. any of several petrels of the genus Pachyptila, located in the oceans of the Southern Hemisphere and having serrated edges on the bill. [1840 50; < NL < Gk príon a saw] prion2 /pree on, pruy /, n. a tiny proteinaceous… …   Universalium

  • Prion (protéine) — Pour les articles homonymes, voir prion. Topologie de la PrPC Un prion est un type d’agent pathogène de nature protéique (const …   Wikipédia en Français

  • prion — Small, infectious proteinaceous particle, of nonnucleic acid composition because of its resistance to nucleases; the causative agent, either on a sporadic, genetic, or infectious basis, of six neurodegenerative diseases in animals, and four in… …   Medical dictionary

  • Prion pseudoknot — The prion pseudoknot is predicted RNA pseudoknot structure found in prion protein mRNA. It has been suggested that this element has a possible effect in prion protein translation. [cite journal | last = Barrette | first = I | coauthors = Poisson… …   Wikipedia

  • prion disease — any of a group of fatal, transmissible neurodegenerative diseases caused by abnormalities of prion protein metabolism, which may result from mutations in the prion protein gene or from infection with pathogenic isoforms of the protein (see prion) …   Medical dictionary

  • Prion (proteine) — Prion (protéine) Pour les articles homonymes, voir prion. Topologie de la PrPC Un prion est un type …   Wikipédia en Français

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