methylenetetrahydrofolate dehydrogenase (NADP+)

methylenetetrahydrofolate dehydrogenase (NADP+)
meth·y·lene·tet·ra·hy·dro·fo·late de·hy·dro·gen·ase (NADP+) (meth″ə-lēn-tet″rə-hi″dro-foґlāt de-hiґdro-jən-ās) [EC 1.5.1.5] an enzyme activity of the oxidoreductase class that catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate, using NADP+ as an electron acceptor. The reaction occurs in the system of folate-mediated one-carbon transfer reactions. The enzyme activity is part of a trifunctional enzyme that also includes methenyltetrahydrofolate cyclohydrolase and formate–tetrahydrofolate ligase activities.

Medical dictionary. 2011.

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