periventricular leukomalacia

periventricular leukomalacia
(PVL) bilateral necrosis of the white matter of the brain adjacent to the lateral ventricles, seen in the neonatal period, especially in premature newborns, and manifested by chalky, yellowish-white plaques in the white matter, with proliferation of astrocytes and microglia; cyst formation may lead to multicystic encephalopathy.

Medical dictionary. 2011.

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