L-lactate dehydrogenase

L-lactate dehydrogenase
L-lac·tate de·hy·dro·gen·ase (LDH) (lakґtāt de-hiґdro-jən-ās) [EC 1.1.1.27] an enzyme of the oxidoreductase class that catalyzes the reduction of pyruvate to (S)-lactate, using NADH as an electron donor. The reaction is the final step in glycolysis (white fibers). The reverse reaction is the first step in the combustion of lactate (heart, red fibers) or its conversion to glucose (liver). The enzyme occurs in the cytoplasm of nearly all cells. It is a tetramer containing M (muscle) and H (heart) subunits; it exists as five distinct isozymes (M4, M3H, M2H2, MH3, H4). Identification of isozyme types in serum is used for clinical diagnosis.

Medical dictionary. 2011.

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  • lactate dehydrogenase — lactate dehydrogenase. См. лактатдегидрогеназа. (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) …   Молекулярная биология и генетика. Толковый словарь.

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  • lactate dehydrogenase — noun : any of a group of isoenzymes that catalyze reversibly the conversion of pyruvic acid to lactic acid, are found especially in the liver, kidneys, striated muscle, and the myocardium, and tend to accumulate in the body when these organs or… …   Useful english dictionary

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  • lactate dehydrogenase — The enzyme that catalyses the formation and removal of lactate according to the equation: pyruvate + NADH = lactate + NAD. The appearance of LDH in the medium is often used as an indication of cell death and the release of cytoplasmic… …   Dictionary of molecular biology

  • lactate dehydrogenase — Biochem. an enzyme that catalyzes the interconversion of pyruvate and lactate, an important step in carbohydrate metabolism: elevated serum levels indicate injury to kidney, skeletal muscle, or heart muscle. Abbr.: LDH * * * …   Universalium

  • lactate dehydrogenase — lac′tate dehy′drogenase n. biochem. an enzyme of carbohydrate metabolism that interchanges lactate and pyruvate: elevated blood levels indicate injury to kidney, heart, or muscles Abbr.: LDH …   From formal English to slang

  • lactate dehydrogenase — /ˌlækteɪt dihaɪˈdrɒdʒəneɪz/ (say .laktayt deehuy drojuhnayz) noun an enzyme existing in multiple forms which catalyses the oxidation of lactate to pyruvic acid used in diagnosis of myocardial infarction …  

  • lactate dehydrogenase — noun Date: 1966 any of a group of isoenzymes that catalyze reversibly the conversion of pyruvic acid to lactic acid called also lactic dehydrogenase …   New Collegiate Dictionary

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