diffuse palmoplantar keratoderma

diffuse palmoplantar keratoderma
any of several hereditary types of palmoplantar keratoderma; most are autosomal dominant, but a rare type, mal de Meleda, is autosomal recessive. They are usually present in infancy but occasionally do not appear until later. The main characteristic is well-demarcated, usually bilateral and symmetrical, confluent areas of scaling on the palms and soles, sometimes spreading to the backs of the hands and feet. Types are now usually distinguished as either epidermolytic or nonepidermolytic palmoplantar keratoderma depending on whether epidermolysis is present.

Medical dictionary. 2011.

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