HIV protease inhibitor

HIV protease inhibitor
any of a group of antiretroviral drugs active against the human immunodeficiency virus; they prevent protease-mediated cleavage of viral polyproteins, causing production of immature viral particles that are noninfective.

Medical dictionary. 2011.

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  • Protease inhibitor (pharmacology) — For natural protease inhibitors, please see protease inhibitor (biology) Protease inhibitors (PIs) are a class of medications used to treat or prevent infection by viruses, including HIV and Hepatitis C. PIs prevents viral replication by… …   Wikipedia

  • Protease-Inhibitor — Protease Inhibitoren (PI) sind Moleküle, die Peptidasen (alter Name: Proteasen) hemmen und damit den Abbau von Proteinen verhindern können. Oft handelt es sich dabei selbst um Proteine. Auch eine Gruppe von Arzneistoffen, die zur Behandlung von… …   Deutsch Wikipedia

  • protease inhibitor — n a substance that inhibits the action of a protease specif any of various drugs (as indinavir or saquinavir) that inhibit the action of HIV protease so that cleavage of viral proteins into mature infectious particles is prevented and that are… …   Medical dictionary

  • HIV-Protease — Vorhandene Strukturdaten: s. UniPr …   Deutsch Wikipedia

  • protease inhibitor — noun an antiviral drug used against HIV; interrupts HIV replication by binding and blocking HIV protease; often used in combination with other drugs • Syn: ↑PI • Hypernyms: ↑antiviral, ↑antiviral agent, ↑antiviral drug • Hyponyms: ↑ …   Useful english dictionary

  • Discovery and development of HIV-protease inhibitors — Many major physiological processes depend on regulation of proteolytic enzyme activity and there can be dramatic consequences when equilibrium between an enzyme and its substrates is disturbed. In this prospective, the discovery of small molecule …   Wikipedia

  • protease inhibitor — noun Date: 1976 a substance that inhibits the action of a protease; specifically any of various drugs (as indinavir) that inhibit the action of the protease of HIV so that the cleavage of viral proteins into mature functional infectious particles …   New Collegiate Dictionary

  • protease inhibitor — any one of a class of drugs used in the treatment of HIV infection and AIDS. Used in combination with other antiretroviral drugs, they act by inhibiting the action of protease, an enzyme produced by HIV that cleaves two precursor proteins into… …   The new mediacal dictionary

  • protease inhibitor — noun A class of drugs used to treat or prevent infection by viruses such as HIV and hepatitis C. See Also: amprenavir, atazanavir, darunavir, fosamprenavir, indinavir, lopinavir, nelfinavir, ritonavir, saquinavir …   Wiktionary

  • Secretory leukocyte protease inhibitor — (SLPI) is a highly cationic single chain protein with eight intramolecular disulfide bonds. It is found in large quantities in bronchial, cervical, and nasal mucosa, saliva, and seminal fluids. SLPI inhibits human leukocyte elastase, human… …   Wikipedia

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