3-hydroxybutyrate dehydrogenase

3-hydroxybutyrate dehydrogenase
3-hy·droxy·bu·ty·rate de·hy·dro·gen·ase (hi-drok″se-buґtə-rāt de-hiґdro-jən-ās) [EC 1.1.1.30] an enzyme of the oxidoreductase class that catalyzes the oxidation of D-3-hydroxybutyrate to form acetoacetate, using NAD+ as an electron acceptor. The enzyme functions in nervous tissues and muscles, enabling use of circulating hydroxybutyrate as a fuel. In the liver mitochondrial matrix, the enzyme can also catalyze the reverse reaction, a step in ketogenesis. Written also β-hydroxybutyrate dehydrogenase.

Medical dictionary. 2011.

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