comparative genomic hybridization

comparative genomic hybridization
(CGH) a cytogenetic technique in which genomic DNA preparations from two sources, reference DNA and the DNA to be studied, as from a tumor, are labeled with two different fluorochromes and then hybridized to a metaphase chromosome spread; copy number changes can be mapped as alterations in the ratio of colors observed.

Medical dictionary. 2011.

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  • Comparative genomic hybridization — (CGH) or Chromosomal Microarray Analysis (CMA) is a molecular cytogenetic method for the analysis of copy number changes (gains/losses) in the DNA content of a given subject s DNA and often in tumor cells. CGH will detect only unbalanced… …   Wikipedia

  • Array comparative genomic hybridization — (also CMA, Chromosomal Microarray Analyisis, Microarray based comparative genomic hybridization, array CGH, a CGH, or aCGH) detects genomic copy number variations at a higher resolution level than chromosome based comparative genomic… …   Wikipedia

  • Comparative (disambiguation) — Contents 1 Language 2 Social sciences 3 Government and law 4 …   Wikipedia

  • Fluorescence in situ hybridization — A metaphase cell positive for the bcr/abl rearrangement (associated with chronic myelogenous leukemia) using FISH. The chromosomes can be seen in blue. The chromosome that is labeled with green and red spots (upper left) is the one where the… …   Wikipedia

  • Fluorescent in situ hybridization — can be used to find out where the fluorescent probe bound to the chromosome. FISH is often used for finding specific features in DNA. These features can be used in genetic counseling, medicine, and species identification. Probes Probes are often… …   Wikipedia

  • Puce d'hybridation génomique comparative — Article principal : hybridation génomique comparative. La puce d hybridation génomique comparative, encore appelée Array comparative genomic hybridization (CGH array, array CGH, a CGH ou aCGH) ou Chromosomal Microarray Analysis (CMA), est… …   Wikipédia en Français

  • CGH — Comparative Genomic Hybridization (Medical » Human Genome) Comparative Genomic Hybridization (Academic & Science) * Computer Generated Holography (Computing » General) * Comparative Genomic Hybridization cytogenetics method (Medical » Oncology) * …   Abbreviations dictionary

  • DNA microarray — A DNA microarray (also commonly known as gene chip, DNA chip, or biochip) is a collection of microscopic DNA spots attached to a solid surface. Scientists use DNA microarrays to measure the expression levels of large numbers of genes… …   Wikipedia

  • Medical genetics — Clinical genetics redirects here. For the journal, see Clinical Genetics (journal). For a non technical introduction to the topic, see Introduction to Genetics. Part of a series on Genetics Key components Chromosome …   Wikipedia

  • Molecular Inversion Probe — (MIP)[1] belongs to the class of Capture by Circularization molecular techniques [1] for performing genomic partitioning, a process through which one captures and enriches specific regions of the genome[2]. Probes used in this technique are… …   Wikipedia

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