A derivative of 6-mercaptopurine, used as a cytotoxic and immunosuppressive agent in organ transplantation and in the treatment of autoimmune diseases such as hemolytic anemias, systemic lupus erythematosus, rheumatoid arthritis and leukemias.

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aza·thi·o·prine .az-ə-'thī-ə-.prēn n a purine antimetabolite C9H7N7O2S that is used esp. as an immunosuppressant see IMURAN

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an immunosuppressant drug, used mainly to aid the survival of organ or tissue transplants. It has also been used in the treatment of inflammatory bowel disease (e.g. ulcerative colitis), rheumatoid arthritis, and myasthenia gravis. Azathioprine may damage bone marrow, causing blood disorders. It may also cause muscle wasting and skin rashes. Trade name: Imuran.

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aza·thio·prine (az″ə-thiґo-prēn) [USP] the imidazolyl derivative of 6-mercaptopurine, its active metabolite; used as an immunosuppressive agent for prevention of transplant rejection in organ transplantation; as a disease-modifying antirheumatic drug for treatment of severe, progressive rheumatoid arthritis unresponsive to other agents; and in treatment of a number of autoimmune disorders, such as systemic lupus erythematosus, autoimmune hemolytic anemia, or inflammatory bowel disease; administered orally.

Medical dictionary. 2011.

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Look at other dictionaries:

  • Azathioprine — formule de structure de l azathioprine Général Nom IUPAC 6 [(1 méthyl 4 nit …   Wikipédia en Français

  • azathioprine — ● azathioprine nom féminin Antimétabolite dérivé de la mercaptopurine, utilisé comme immunodépresseur dans les transplantations d organes et les maladies auto immunes …   Encyclopédie Universelle

  • azathioprine — [az΄ə thī′ə prēn΄] n. [aza (< AZO ) + THIO + P(U)RINE] an immunosuppressive drug, C9H7N7O2S, used to prevent rejections in transplant surgery …   English World dictionary

  • Azathioprine — Drugbox IUPAC name = 6 (3 methyl 5 nitro imidazol 4 yl)sulfanyl 7 H purine width=200 CAS number=446 86 6 ChemSpiderID=2178 ATC prefix=L04 ATC suffix=AX01 ATC supplemental= PubChem=2265 DrugBank=APRD00811 C=9 | H=7 | N=7 | O=2 | S=1 molecular… …   Wikipedia

  • azathioprine — /az euh thuy euh preen /, n. Pharm. a cytotoxic purine analog, C9H7N7O2S, used as an immunosuppressive in organ transplantations and in rheumatoid arthritis and connective tissue disorders. [1960 65; coinage appar. based on imidazol, THIO , and… …   Universalium

  • azathioprine — n. an immunosuppressant drug, used mainly to aid the survival of organ or tissue transplants. It may also be used in the treatment of rheumatoid arthritis (see disease modifying antirheumatic drug) and myasthenia gravis. Azathioprine may damage… …   The new mediacal dictionary

  • azathioprine — noun an immunosuppressive drug (trade name Imuran) used to prevent rejection of a transplanted organ • Syn: ↑Imuran • Usage Domain: ↑trademark (for: ↑Imuran) • Hypernyms: ↑medicine, ↑ …   Useful english dictionary

  • azathioprine sodium — [USP] the sodium salt of azathioprine, used to prevent transplant rejection in organ transplantation; administered intravenously …   Medical dictionary

  • azathioprine — noun Etymology: aza + thi + purine Date: 1962 a purine antimetabolite C9H7N7O2S used especially as an immunosuppressant …   New Collegiate Dictionary

  • azathioprine — noun A particular immunosuppressant …   Wiktionary

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