glycerol-3-phosphate dehydrogenase (NAD+)

glycerol-3-phosphate dehydrogenase (NAD+)
glyc·er·ol-3-phos·phate de·hy·dro·gen·ase (NAD+) (glisґər-ol fosґfāt de-hiґdro-jən-ās) [EC 1.1.1.8] a cytosolic enzyme of the oxidoreductase class that catalyzes the oxidation of glycerol 3-phosphate to dihydroxyacetone phosphate, with NAD+ as the electron acceptor. NADH formed from NAD+ by other reactions displaces the equilibrium, producing glycerol 3-phosphate and the oxidized nucleotide NAD+. The glycerol phosphate produced can cross into the mitochondria, where it is reoxidized by glycerol-3-phosphate dehydrogenase, regenerating dihydroxyacetone phosphate and donating electrons to FAD. See also glycerol phosphate shuttle, under shuttle.

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