glutamate formiminotransferase

glutamate formiminotransferase
glu·ta·mate for·mim·i·no·trans·fer·ase (glooґtə-māt for-mim″ĭ-no-transґfər-ās) [EC 2.1.2.5] an enzyme of the transferase class that catalyzes the transfer of a formimino group from formiminoglutamate to tetrahydrofolate, forming 5-formiminotetrahydrofolate. The reaction is a step in the degradation of histidine. The enzyme is bifunctional; it also contains a catalytic site with formiminotetrahydrofolate cyclodeaminase (q.v.) activity. Urinary excretion of formiminoglutamate and mental retardation have been associated with decreased enzyme activity, resulting from either a genetic disorder or a deficiency of tetrahydrofolate. Called also formiminotransferase.

Medical dictionary. 2011.

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  • formiminotransferase — for·mim·i·no·trans·fer·ase (for mim″ĭ no transґfər ās) any enzyme that transfers a formimino group; usually used to refer to glutamate formiminotransferase …   Medical dictionary

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  • Cyclodeaminase domain — FTCD C crystal structure of formiminotetrahydrofolate cyclodeaminase (tm1560) from thermotoga maritima at 2.80 a resolution Identifiers Symbol FTCD C …   Wikipedia

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