fatty-acid synthase

fatty-acid synthase
fat·ty-ac·id syn·thase (fatґe asґid sinґthās) [EC] an enzyme complex that catalyzes the synthesis of long-chain fatty acids. Two-carbon units are successively added to the growing chain in a process similar to fatty acid oxidation in reverse, with each unit added via a series of condensation and decarboxylation, reduction, and dehydration reactions. The overall reaction is: acetyl CoA + n malonyl CoA + 2n NADPH = long-chain fatty acid anion + n CO2 + 2n NADP+ + (n + 1) CoA. Palmitate is the preferred product of the mammalian liver enzyme complex, which includes catalytic sites for the seven sequential reactions.

Medical dictionary. 2011.

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  • Fatty-acyl-CoA synthase — In enzymology, a fatty acyl CoA synthase (EC number| is an enzyme that catalyzes the chemical reaction:acetyl CoA + n malonyl CoA + 2n NADH + 2n NADPH + 4n H+ ightleftharpoons long chain acyl CoA + n CoA + n CO2 + 2n NAD+ + 2n NADP+The 3 …   Wikipedia

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