colony-stimulating factors
- colony-stimulating factors
- a group of glycoprotein lymphokine growth factors produced by blood monocytes, tissue macrophages, and stimulated lymphocytes; they are required for differentiation of stem cells into granulocyte and monocyte cell colonies, and were originally named according to their ability to stimulate the production of morphologically distinguishable myeloid cell colonies in vitro. In vivo, they stimulate the production of granulocytes and macrophages and enhance the actions of mature cells. Colony-stimulating factors can be produced by recombinant DNA techniques and have been used experimentally as anticancer agents and for the restoration of hematopoietic function after myelosuppression in transplantation and cancer chemotherapy.
Medical dictionary.
2011.
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colony stimulating factors — plural noun (immunology) Substances which cause blood forming stem cells to proliferate and differentiate into colonies of mature blood cells • • • Main Entry: ↑colony … Useful english dictionary
Colony-stimulating factor — Colony stimulating factors (CSFs) are secreted glycoproteins that bind to receptor proteins on the surfaces of hemopoietic stem cells, thereby activating intracellular signaling pathways that can cause the cells to proliferate and differentiate… … Wikipedia
Colony-stimulating factor — A laboratory made agent similar to a substance in the body that stimulates the production of blood cells. Treatment with colony stimulating factors (CSFs) can help the blood forming tissue recover from the effects of chemotherapy and radiation… … Medical dictionary
colony-stimulating factor — A substance that stimulates the production of blood cells. Colony stimulating factors include granulocyte colony stimulating factor (G CSF), granulocyte macrophage colony stimulating factor (GM CSF), and promegapoietin … English dictionary of cancer terms
Macrophage colony-stimulating factor — Colony stimulating factor 1 (macrophage) PDB rendering based on 1hmc … Wikipedia
colony-stimulating factor — CSF one of a group of substances (haemopoietic growth factors or hormones) that are produced in the bone marrow and stimulate the production of specific blood cells. Genetically engineered granulocyte colony stimulating factor (G CSF) stimulates… … The new mediacal dictionary
Granulocyte colony-stimulating factor — Not to be confused with granulocyte macrophage colony stimulating factor. Colony stimulating factor 3 (granulocyte) Crystal structure of 3 molecules of human G CSF. From PDB … Wikipedia
Granulocyte macrophage colony-stimulating factor — Not to be confused with granulocyte colony stimulating factor. Colony stimulating factor 2 (granulocyte macrophage) PDB rendering based on 2gmf … Wikipedia
Factor, colony-stimulating — A laboratory made agent similar to a normally existing substance in the body that stimulates the production of blood cells. The colony stimulating factors (CSFs) include granulocyte colony stimulating factors (G CSF) and granulocyte macrophage… … Medical dictionary
CSF (colony-stimulating factor) — A laboratory made agent similar to a substance in the body that stimulates the production of blood cells. The colony stimulating factors (CSFs) include granulocyte colony stimulating factor (G CSF) and granulocyte macrophage colony stimulating… … Medical dictionary
