allelic exclusion

allelic exclusion
a mechanism that allows the expression of only one of a set of alleles, such as the expression of a single immunoglobulin by any one B lymphocyte or plasma cell or the expression of a single T cell receptor by any one T lymphocyte.

Medical dictionary. 2011.

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  • allelic exclusion — A phenomenon whereby only one functional allele of an antibody gene can be assembled in a given B lymphocyte …   Glossary of Biotechnology

  • exclusion — A shutting out; disconnection from the main portion. [L. ex cludo, pp. clusus, to shut out] allelic e. in each cell of an individual heterozygous at an autosomal locus, the non preferential suppression of the phenotypic manifestation of one or… …   Medical dictionary

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  • Adaptive immune system — The adaptive immune system is composed of highly specialized, systemic cells and processes that eliminate or prevent pathogenic challenges. Thought to have arisen in the first jawed vertebrates, the adaptive or specific immune system is activated …   Wikipedia

  • Antonio Lanzavecchia — (born October 9, 1951) is an Italian immunologist. He was born in Varese, Italy. In 1976 he obtained his degree with honors in Medicine at the University of Pavia where he specialized in Pediatrics and Infectious Diseases. From 1983 to 1999 he… …   Wikipedia

  • IGLL1 — Immunoglobulin lambda like polypeptide 1, also known as IGLL1, is a human gene.cite web | title = Entrez Gene: IGLL1 immunoglobulin lambda like polypeptide 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView… …   Wikipedia

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