DNA ligase

DNA ligase
DNA li·gase (liґgās) an enzyme of the ligase class that catalyzes the energy-driven linkage of a double-stranded DNA chain with a free 3′ hydroxyl group to one with a 5′ phosphate group, forming a phosphodiester bond between them. The reaction is important in the repair of damaged DNA and in the joining of Okazaki fragments during DNA replication. In animals and bacteriophages, the enzyme uses ATP as an energy source and is officially called DNA ligase (ATP) [EC]. In bacteria, it uses NAD as the energy source and the enzyme is officially called DNA ligase (NAD) [EC]. Both are used in vitro in the formation of recombinant molecules.

Medical dictionary. 2011.

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  • DNA ligase — repairing chromosomal damage Identifiers EC number …   Wikipedia

  • DNA-Ligase — Bezeichner Externe IDs CAS Nummer:&# …   Deutsch Wikipedia

  • DNA ligase — ligase ligase n. (Biochem.) An enzyme which catalyzes creation of a covalent bond between two substrates, resulting in a larger product which is a combination of the two starting materials; especially, {DNA ligase}, an enzyme which creates a… …   The Collaborative International Dictionary of English

  • DNA-Ligase — DNA Ligase,   Molekulargenetik: Enzym, das DNA Fragmente unter Ausbildung einer Esterbindung zwischen Phosphorsäure und Desoxyribose verknüpft. DNA L. spielt v. a. eine Rolle bei der Reparatur von DNA Schäden (DNA Reparatur) sowie bei der… …   Universal-Lexikon

  • DNA ligase — Enzyme involved in DNA replication. The DNA ligase of E. coliseals nicks in one strand of double stranded DNA, a reaction required for linking precursor fragments during discontinuous synthesis on the lagging strand. Nicks are breaks in the… …   Dictionary of molecular biology

  • DNA ligase — DNR ligazė statusas T sritis chemija apibrėžtis Fermentas, sujungiantis viengrandės DNR fragmentus fosfodiesteriniu ryšiu esant komplementariai DNR matricai. atitikmenys: angl. DNA ligase rus. ДНК лигаза …   Chemijos terminų aiškinamasis žodynas

  • DNA ligase — An enzyme that catalyses a reaction to link two separate DNA molecules via the formation of a phosphodiester bond between the 3 hydroxyl end of one and the 5 phosphate of the other. Its natural role lies in DNA repair and replication. An… …   Glossary of Biotechnology

  • DNA ligase — An enzyme that joins two DNA fragments together through the formation of a new phosphodiester bond …   Dictionary of microbiology

  • DNA ligase —    An enzyme that catalyzes nucleotide phisphodiester bond formation …   Forensic science glossary

  • DNA-Replikation — DNA Replikation. Die Doppelhelix wird durch die Helicase und die Topoisomerase geöffnet. Danach setzt die Primase einen Primer und die …   Deutsch Wikipedia

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