DNA ligase

DNA ligase
DNA li·gase (liґgās) an enzyme of the ligase class that catalyzes the energy-driven linkage of a double-stranded DNA chain with a free 3′ hydroxyl group to one with a 5′ phosphate group, forming a phosphodiester bond between them. The reaction is important in the repair of damaged DNA and in the joining of Okazaki fragments during DNA replication. In animals and bacteriophages, the enzyme uses ATP as an energy source and is officially called DNA ligase (ATP) [EC 6.5.1.1]. In bacteria, it uses NAD as the energy source and the enzyme is officially called DNA ligase (NAD) [EC 6.5.1.2]. Both are used in vitro in the formation of recombinant molecules.

Medical dictionary. 2011.

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  • DNA ligase — An enzyme that catalyses a reaction to link two separate DNA molecules via the formation of a phosphodiester bond between the 3 hydroxyl end of one and the 5 phosphate of the other. Its natural role lies in DNA repair and replication. An… …   Glossary of Biotechnology

  • DNA ligase — An enzyme that joins two DNA fragments together through the formation of a new phosphodiester bond …   Dictionary of microbiology

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