Dowling-Degos disease

Dowling-Degos disease
a rare, autosomal dominant pigmentary genodermatosis caused by mutations in the KRT5 gene (locus:12q13), which encodes keratin 5, characterized by brownish black macules in a reticular pattern in the axillary, inguinal, and submammary folds; the neck, scalp, trunk, and arms may be involved and pitted acneiform scars may occur at the angles of the mouth. Onset is usually in the fourth decade of life. Cf. reticulate acropigmenation of Kitamura.

Medical dictionary. 2011.

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