protein denaturation

protein denaturation
disruption of the configuration (tertiary structure) of a protein, as by heat, change in pH, or other physical or chemical means, resulting in alteration of the physical properties and loss of biological activity of the protein.

Medical dictionary. 2011.

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  • protein — proteinaceous /proh tee nay sheuhs, tee i nay /, proteinic, proteinous, adj. /proh teen, tee in/, n. 1. Biochem. any of numerous, highly varied organic molecules constituting a large portion of the mass of every life form and necessary in the… …   Universalium

  • Denaturation (biochemistry) — This egg s protein has undergone denaturation and loss of solubility, caused by the high rise of the temperature of the egg during the cooking process. Denaturation is a process in which proteins or nucleic acids lose their tertiary structure and …   Wikipedia

  • denaturation — See denaturant. * * * Biochemical process modifying a protein s natural configuration. It involves breaking many weak (hydrogen and hydrophobic) bonds (see bonding) that maintain the protein s highly ordered structure. This usually results in… …   Universalium

  • Protein folding — Protein thermodynamics redirects here. For the thermodynamics of reactions catalyzed by proteins, see Enzyme. Protein before and after folding. Protein folding is the process by which a protein structure assumes its functional shape or… …   Wikipedia

  • Protein purification — is a series of processes intended to isolate a single type of protein from a complex mixture. Protein purification is vital for the characterisation of the function, structure and interactions of the protein of interest. The starting material is… …   Wikipedia

  • Protein — Proteins are large organic compounds made of amino acids arranged in a linear chain and joined together by peptide bonds between the carboxyl and amino groups of adjacent amino acid residues. The sequence of amino acids in a protein is defined by …   Wikipedia

  • Protein precipitation — Precipitation is widely used in downstream processing of biological products, such as proteins. [http://www.rcsb.org/pdb/home/home.do] This unit operation serves to concentrate and fractionate the target product from various contaminants. For… …   Wikipedia

  • Denaturation midpoint — Main articles: Protein folding and Chevron plot Assuming two state protein folding, denaturation midpoint is defined as that temperature (Tm) or denaturant concentration (Cm) at which both the folded and unfolded states are equally populated at… …   Wikipedia

  • denaturation — The process of becoming denatured. * * * de·na·tur·ation (.)dē .nā chə rā shən n the process of denaturing * * * n. the changes in the physical and physiological properties of a protein that are brought about by heat, X rays, or chemicals. These… …   Medical dictionary

  • denaturation — noun a) The deliberate addition of a noxious substance to alcohol to make it unfit to drink b) The change of folding structure of a protein (and thus of physical properties) caused by heating, changes in pH, or exposure to certain chemicals …   Wiktionary

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