The substrate for renin whereupon through enzymatic action angiotensin I is liberated; an abundant α2-globulin that circulates in the blood plasma. SYN: angiotensin precursor.

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an·gio·ten·sin·o·gen -ten(t)-'sin-ə-jən n a serum globulin formed by the liver that is cleaved by renin to produce angiotensin I called also hypertensinogen

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an·gio·ten·sin·o·gen (an″je-o-ten-sinґo-jen) a serum α2-globulin secreted in the liver and produced in many organs, which is cleaved by renin to give rise to angiotensin I. Called also renin substrate.

Medical dictionary. 2011.

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