primary biliary cirrhosis

primary biliary cirrhosis
a type of cirrhosis with an unknown etiology, now known to be unrelated to biliary cirrhosis; it usually affects middle-aged to elderly women and involves destruction of small intrahepatic bile ducts while the major intrahepatic and extrahepatic ducts remain patent. Characteristics include chronic cholestasis with pruritus, jaundice, hypercholesterolemia, xanthomas, osteomalacia, and eventually portal hypertension and liver failure. Almost all patients have circulating antimitochondrial antibodies. Called also chronic nonsuppurative destructive cholangitis and progressive nonsuppurative cholangitis.

Medical dictionary. 2011.

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