first-generation cephalosporin

first-generation cephalosporin
any of the group containing the first cephalosporins developed, comprising agents with a broad range of activity against gram-positive organisms but a narrow range of activity against gram-negative organisms and including cefadroxil, cefazolin, cephalexin, cephalothin, cephapirin, and cephradine.

Medical dictionary. 2011.

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  • second-generation cephalosporin — any of a group containing cephalosporins that have greater resistance to β lactamases and so are more active against gram negative organisms, but are slightly less active against gram positive organisms than are first generation agents; it… …   Medical dictionary

  • Cephalosporin — See also: Discovery and development of cephalosporins Core structure of the cephalosporins …   Wikipedia

  • cephalosporin — /sef euh loh spawr in, spohr /, n. Pharm. any of a group of widely used broad spectrum antibiotics, originally isolated as a product of fermentation from the fungus Cephalosporium acremonium. [1950 55; < NL Cephalospor(ium) the genus (see CEPHALO …   Universalium

  • cephalosporin — n. any one of a group of semisynthetic beta lactam antibiotics, derived from the mould Cephalosporium, which are effective against a wide range of microorganisms and are therefore used in a variety of infections. The older (first generation)… …   The new mediacal dictionary

  • Discovery and development of cephalosporins — Cephalosporins are a broad class of bactericidal antibiotics that include the β lactam ring and share a structural similarity and mechanism of action with other β lactam antibiotics (e.g. penicillins, carbapenems and aztreonam).[1] The… …   Wikipedia

  • Cefalexin — Systematic (IUPAC) name (6R,7R) 7 {[(2R) 2 amino 2 phenylacetyl]amino} 3 methyl 8 oxo 5 thia 1 azabicyclo[4.2.0]oct 2 ene 2 carboxylic acid Clinical data …   Wikipedia

  • Cefalotin — Systematic (IUPAC) name (6R,7R) 3 [(acetoxy)methyl] 8 oxo 7 [(2 thienylacetyl)amino] 5 thia 1 azabicyclo[4.2.0]oct 2 ene 2 carboxylic acid Clinical data …   Wikipedia

  • cefazolin — A broad spectrum cephalosporin antibiotic used to treat a wide variety of serious infections; available as the sodium salt for intramuscular or intravenous administration. * * * ce·faz·o·lin si faz ə lən n a semisynthetic cephalosporin antibiotic …   Medical dictionary

  • Cefadroxil — Systematic (IUPAC) name (6R,7R) 7 {[(2R) 2 amino 2 (4 hydroxyphenyl)acetyl]amino} 3 methyl 8 oxo 5 thia 1 azabicyclo[4.2.0]oct 2 ene 2 carboxylic acid Clinical data …   Wikipedia

  • Cefaloglycin — Systematic (IUPAC) name (6R,7R) 3 [(acetyloxy)methyl] 7 {[(2R) 2 amino 2 phenylacetyl]amino} 8 oxo 5 thia 1 azabicyclo[4.2.0]oct 2 ene 2 carboxylic acid Clinical data …   Wikipedia

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