hereditary nonpolyposis colorectal cancer

hereditary nonpolyposis colorectal cancer
(HNPCC) a group of hereditary, autosomal dominant cancers characterized by discrete adenomas of the colon and rectum without polyposis. Two types have been distinguished: in type 1, all affected persons have colorectal cancers; in type 2, some family members have cancer in other parts of the body, such as the female genital tract, stomach, brain, breast, or urinary tract. Both types are caused by mutations in mismatch repair genes, particularly MSH2 (locus: 2p22-p21) and MLH1 (locus: 3p21.3), and are characterized by microsatellite instability. Called also Lynch syndrome. Type 2 is also called cancer family syndrome.

Medical dictionary. 2011.

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