Rh blood group

Rh blood group
the most complex of all human blood groups because the genes differ by determining different numbers of antigens (Rh factors) and do so with remarkably different quality; over 40 antigens have been described to date. People of African descent show the greatest degree of diversity and East Asians the least. The major antigen, Rh1 (Rh0, D, or Rh0D), is highly immunogenic and before the development of passive immunization prophylaxis it was responsible for serious hemolytic disease of the newborn. Two other pairs of alternative antigens are inherited with or without Rh1; these are Rh21 (rhG or CG) and Rh4 (hr′ or c), and Rh3 (rh′ or E) and Rh5 (hr′ or e). The most common groups of antigens are R−1,−3,−21 (in Caucasians), R1,−3,−21 (in blacks), R1,−3,21 (in East Asians and Caucasians), and R1,3,−21 (in East Asians and Caucasians). Another antigen Rh10 (hrv, V) is common in blacks.

Medical dictionary. 2011.

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