Aurora kinase

Aurora kinase
Au·ro·ra ki·nase (ə-roґrə kiґnās) [the aurora locus of Drosophila] any of a family of protein kinases that catalyze phosphorylation of serine and threonine and are key regulators of mitosis; they are involved in centrosome separation and maturation, spindle assembly and stability, chromosome segregation, and cytokinesis. There are three mammalian Aurora kinases, designated A, B, and C; overexpression occurs in a number of malignancies and they can be used as markers of tumor progression and prognosis. Written also aurora kinase.

Medical dictionary. 2011.

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  • Aurora kinase — Aurora kinases are serine/threonine kinases that are essential for cell proliferation. The enzyme helps the dividing cell share its genetic materials with its daughter cells. More specifically, Aurora kinases play a crucial role in cellular… …   Wikipedia

  • Aurora kinase inhibitor AT9283 — A substance being studied in the treatment of some types of cancer. It blocks enzymes (Aurora kinases) involved in cell division and may kill cancer cells. Aurora kinase inhibitor AT9283 is a type of serine/threonine protein kinase inhibitor.… …   English dictionary of cancer terms

  • Aurora A kinase — Aurora A is a member of a family of mitotic serine/threonine kinases. It is implicated with important processes during mitosis and meiosis whose proper function is integral for healthy cell proliferation. Aurora A is activated by one or more… …   Wikipedia

  • Aurora inhibitors — Aurora kinases regulate cell cycle transit from G2 through cytokinesis and, thus, are targets in cancer therapy [Andrews PD, Knatko E, Moore WJ, Swedlow JR. Mitotic mechanics: the auroras come into view. Current Opin in Cell Biol.(2003) 15:… …   Wikipedia

  • Aurora B kinase — is a human protein that functions in the attachment of the mitotic spindle to the centromere. PBB Summary section title = summary text = Chromosomal segregation during mitosis as well as meiosis is regulated by kinases and phosphatases. The… …   Wikipedia

  • Aurora — most commonly refers to: *Aurora (astronomy), a glow in the sky seen at polar latitudes, commonly referred to as the northern lights or the southern lights *Aurora (mythology), the goddess of the dawn in Roman mythologyAurora may also… …   Wikipedia

  • Protein kinase A — In cell biology, Protein kinase A (PKA) refers to a family of enzymes whose activity is dependent on cellular levels of cyclic AMP (cAMP). PKA is also known as cAMP dependent protein kinase (EC 2.7.11.11). Protein kinase A has several functions… …   Wikipedia

  • Mitogen-activated protein kinase — Identifiers EC number 2.7.11.24 CAS number 142243 02 5 …   Wikipedia

  • MAP kinase kinase kinase — (or MAP3K or MEKK) is a serine/threonine specific protein kinase which acts upon MAP kinase kinase. In humans there are at least 19 genes: MAP3K1 (aka MEKK1) MAP3K2 MAP3K3 (aka MEKK3) MAP3K4 MAP3K5 (aka ASK1) MAP3K6 (aka ASK2) MAP3K7 (aka MEKK7)… …   Wikipedia

  • Ca2+/calmodulin-dependent protein kinase — Calcium/calmodulin dependent protein kinase II association domain crystal structure of calcium/calmodulin dependent protein kinase Identifiers Symbol CaMKII AD …   Wikipedia

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