Donath-Landsteiner antibody

Donath-Landsteiner antibody
an IgG antibody directed against the P blood group antigen; it binds to red cells at low temperatures and induces complement-mediated lysis on warming, and is responsible for hemolysis in paroxysmal cold hemoglobinuria.

Medical dictionary. 2011.

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  • Donath-Landsteiner antibody test — Do·nath Land·stein·er antibody, test (doґnaht landґsti nər) [Julius Donath, Austrian immunologist, 1870–1950; Karl Landsteiner, Austrian physician in United States, 1868–1943] see under antibody and test …   Medical dictionary

  • Donath-Landsteiner test — (for paroxysmal cold hemoglobinuria) a test based on the fact that the blood of patients with this disease contains complement dependent iso and autohemolysin (Donath Landsteiner antibody) which unites with red cells only at low temperatures (2°… …   Medical dictionary

  • D-L — Donath Landsteiner [antibody] …   Medical dictionary

  • D-L — • Donath Landsteiner [antibody] …   Dictionary of medical acronyms & abbreviations

  • DL — Donath Landsteiner [antibody] * * * DL abbr danger list * * * diffusing capacity of the lung; DLO2 denotes diffusing capacity for oxygen, DLCO, diffusing capacity for carbon monoxide, etc …   Medical dictionary

  • paroxysmal cold hemoglobinuria — an autoimmune or postviral disease marked by episodes of hemoglobinemia and hemoglobinuria after exposure to cold, caused by complement dependent hemolysis due to IgG antibody (Donath Landsteiner antibody) directed against the P blood group… …   Medical dictionary

  • Autoagglutination — represents clumping of an individual s red blood cells (RBCs or erythrocytes) by his or her own serum due to the RBCs being coated on their surface by antibodies.Autoagglutination is seen to occur in a type of immune mediated hemolytic anemia… …   Wikipedia

  • P antigen — Antigenic determinant on the surface of human red blood cells to which the Donath Landsteiner antibody reacts. This antibody binds in the cold (a cold IgG ), but elutes from red cells at 37°C, is particularly associated with tertiary syphylis,… …   Dictionary of molecular biology

  • DL — • danger list; • data language; • deep lobe; • De Lee [catheter]; • description language; • description logic; • developmental level; • diagnostic laparoscopy; • difference limen; • digital library; • dipole layer; • direct laryngoscopy; •… …   Dictionary of medical acronyms & abbreviations

  • autoantibody — Antibody occurring in response to antigenic constituents of the host s tissue against self antigen, and which reacts with the inciting tissue component. antiidiotype a. SYN: idiotype a..antiidiotype antibody. cold a. an a. that reacts at… …   Medical dictionary

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