Candidate gene for otosclerosis located at 15q25 to q26.

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ag·gre·can (agґrə-kan) the major structural proteoglycan of cartilage, consisting of a 210-kD core protein to which are linked about 100 chondroitin sulfate and a number of keratan sulfate and oligosaccharide chains; it binds to a link protein and to hyaluronan, creating large aggregates.

Medical dictionary. 2011.

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