pyrimidine analogue

pyrimidine analogue
a structural analogue of one of the pyrimidine bases (e.g., cytosine, thymine, uracil), able to inhibit the biosynthesis of pyrimidine bases or to mimic them such that the analogues interfere with the synthesis or function of nucleic acids. Their clinical uses include antineoplastic, antipsoriatic, antiviral, and antifungal agents.

Medical dictionary. 2011.

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  • Pyrimidine analogue — Pyrimidine analogues are antimetabolites which mimic the structure of metabolic pyrimidines.ExamplesExamples include:* 5 fluorouracil (5FU) which inhibits thymidylate synthase. * Floxuridine (FUDR) * Cytosine arabinoside (Cytarabine) …   Wikipedia

  • Nucleoside analogue — Nucleoside analogues are a range of antiviral products used to prevent viral replication in infected cells. The most commonly used is Acyclovir, although its inclusion in this category is uncertain, as it contains only a partial nucleoside… …   Wikipedia

  • nucleoside analogue — a structural analogue of a nucleoside, including both purine analogues and pyrimidine analogues …   Medical dictionary

  • base analogue — A non natural purine or pyrimidine base that differs slightly in structure from the normal bases, but can be incorporated into nucleic acids. They are often mutagenic …   Glossary of Biotechnology

  • Nucleotide — Nucleotides are molecules that, when joined together, make up the structural units of RNA and DNA. In addition, nucleotides participate in cellular signaling (cGMP and cAMP), and are incorporated into important cofactors of enzymatic reactions… …   Wikipedia

  • Uracil — Uracil …   Wikipedia

  • Nucleobase — Base pairing in RNA. Nucleobases in blue. Hydrogen bonds in red. Nucleobases are a group of nitrogen based molecules that are required to form nucleotides, the basic building blocks of DNA and RNA. Nucleobases provide the molecular structure… …   Wikipedia

  • Cytosine — Cytosine …   Wikipedia

  • Thymidine — Identifiers CAS number 50 89 5  …   Wikipedia

  • Cytidine triphosphate — IUPAC name [(2R,3S,4R,5R) 5 (4 amino 2 oxopyrimidin 1 yl) 3,4 dihydroxyoxolan 2 yl]methyl(hydroxy phosphon …   Wikipedia

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